The John F. Kennedy Expressway is a nearly 18-mile-long (29 km) freeway in Chicago, Illinois, United States. Portions of the freeway carry I-190, I-90 and I-94. The freeway runs in a southeast–northwest direction between the central city neighborhood of the West Loop and O'Hare International Airport. The highway was named in commemoration of 35th US President John F. Kennedy. It conforms to the Chicago-area term of using the word expressway for an Interstate Highway without tolls. The Kennedy's official endpoints are the Jane Byrne Interchange with Interstate 290 and the Dan Ryan Expressway at the east end, and the O'Hare Airport terminals at the west end. I-190 runs from the western terminus at O'Hare Airport for 3.07 miles (4.94 km), where it meets I-90 and runs a further 6.29 miles (10.12 km), before joining with I-94 for the final 8.44 miles (13.58 km).

Interstate 90 (I-90) in the US state of Illinois runs roughly northwest-to-southeast through the northern part of the state. From the Wisconsin state line at South Beloit, it heads south to Rockford before heading east-southeast to the Indiana state line at Chicago. I-90 traverses 124 miles (200 km) through a variety of settings, from farmland west of the Fox River Valley through the medium-density suburbs west of O'Hare International Airport, through Downtown Chicago, and through the heart of the industrial southeast side of Chicago before entering Indiana.