The Kingdom of Kartli-Kakheti was created in 1762 by the unification of the two eastern Georgian kingdoms of Kartli and Kakheti. From the early 16th century, according to the 1555 Peace of Amasya, these two kingdoms were under Iranian control. In 1744, Nader Shah granted the kingship of Kartli to Teimuraz II and that of Kakheti to his son Heraclius II, as a reward for their loyalty. When Nader Shah died in 1747, Teimuraz II and Heraclius II capitalized on the instability in Iran proper, and declared de facto independence. After Teimuraz II died in 1762, Heraclius succeeded him as ruler of Kartli, thus unifying the two kingdoms.

The Kingdom of Kakheti was a late medieval/early modern monarchy in eastern Georgia, centered at the province of Kakheti, with its capital first at Gremi and then at Telavi. It emerged in the process of a tripartite division of the Kingdom of Georgia in 1465 and existed, with several brief intermissions, until 1762 when Kakheti and the neighboring Georgian Kingdom of Kartli were merged through a dynastic succession under the Kakhetian branch of the Bagrationi dynasty. Through much of this period, the kingdom was a vassal of the successive dynasties of Iran, and to a much shorter period Ottoman Empire, but enjoyed intermittent periods of greater independence, especially after 1747.