Kingston Pike is a highway in Knox County, Tennessee, United States, that connects Downtown Knoxville with West Knoxville, Farragut, and other communities in the western part of the county. The road follows a merged stretch of U.S. Route 11 (US 11) and US 70. From its initial construction in the 1790s until the development of the Interstate Highway System in the 1960s, Kingston Pike was the main traffic artery in western Knox County, and an important section of several cross-country highways. The road is now a major commercial corridor, containing hundreds of stores, restaurants, and other retail establishments.

Knox County is located in the U.S. state of Tennessee. As of the 2020 census, the population was 478,971, making it the third-most populous county in Tennessee. Its county seat is Knoxville, which is the third-most populous city in Tennessee. Knox County is included in the Knoxville metropolitan area. The county is located at the geographical center of the Great Valley of East Tennessee. Near the heart of the county is the origin of the Tennessee River, at the confluence of the Holston and French Broad rivers.