Lady Jessica is a fictional character in the Dune universe created by Frank Herbert. A main character in the 1963–65 novel Dune, Jessica also plays an important role in the later installment Children of Dune (1976). The events surrounding Jessica's conception, her birth and her early years with Leto are chronicled in the Prelude to Dune prequel trilogy (1999–2001) and the Caladan Trilogy (2020–2022) by Brian Herbert and Kevin J. Anderson. The character is brought back as a ghola in the Herbert/Anderson sequels which conclude the original series, Hunters of Dune (2006) and Sandworms of Dune (2007).

Dune is an American science fiction media franchise that originated with the 1965 novel Dune by Frank Herbert and has continued to add new publications. Dune is frequently described as the best-selling science fiction novel in history. It won the inaugural Nebula Award for Best Novel and the Hugo Award in 1966 and was later adapted into a 1984 film, a 2000 television miniseries, and a two-part film series with the first film in 2021 and a sequel in 2024. Herbert wrote five sequels, the first two of which were concomitantly adapted as a 2003 miniseries. Dune has also inspired tabletop games and a series of video games. Since 2009, the names of planets from the Dune novels have been adopted for the real-world nomenclature of plains and other features on Saturn's moon Titan.