Laodice V was a Seleucid princess. Through marriage to Perseus king of Macedon she was a Queen of the ruling Antigonid dynasty in Macedonia and possibly later of the Seleucid dynasty.

Perseus was king of the ancient kingdom of Macedon from 179 until 168 BC. He is widely regarded as the last king of Macedonia and the last ruler from the Antigonid Dynasty, as his defeat by Rome at the Battle of Pydna during the Third Macedonian War effectively ended Macedonia as an independent political entity.