Lawrence County is a county located in the U.S. state of Kentucky. As of the 2020 census, the population was 16,293. Its county seat is Louisa. The county is named for James Lawrence, and co-founded by Isaac Bolt, who served as a Lawrence County Commissioner and Justice of the Peace. Lawrence County is the home of bluegrass music and country music star Tyler Childers. It is the birthplace of the late Chief Justice of the United States Frederick Moore Vinson and former Kentucky Governor Paul E. Patton. In regard to alcoholic beverage sales, Lawrence County is considered a "moist" county, meaning alcohol sales are only allowed within the city limits of Louisa. There are no alcohol sales within the rest of the county. Only two stores sell liquor, and most convenience stores sell beer and malted beverages.

Louisa is a home-rule class city located in eastern Kentucky at the merger of the Levisa and Tug Forks into the Big Sandy River, which forms part of the state's border with West Virginia. It is the seat of Lawrence County. The population was 2,467 at the 2010 census and an estimated 2,375 in 2018.