Lee County is the southernmost county in the U.S. state of Iowa. As of the 2020 census, the population was 33,555. The county seats are Fort Madison and Keokuk. Lee County is part of the Fort Madison–Keokuk, IA–IL–MO Micropolitan Statistical Area. It was established in 1836.

Iowa is a landlocked state in the upper Midwestern region of the United States. It borders the Mississippi River to the east and the Missouri River and Big Sioux River to the west; Wisconsin to the northeast, Illinois to the east and southeast, Missouri to the south, Nebraska to the west, South Dakota to the northwest, and Minnesota to the north.