Liberalism in Mexico was part of a broader nineteenth-century political trend affecting Western Europe and the Americas, including the United States, that challenged entrenched power. In Mexico, liberalism sought to make fundamental the equality of individuals before the law, rather than their benefiting from special privileges of corporate entities, especially the Roman Catholic Church, the military, and indigenous communities. Liberalism viewed universal, free, secular education as the means to transform Mexico's citizenry. Early nineteenth-century liberals promoted the idea of economic development in the overwhelmingly rural country where much land was owned by the Catholic Church and held in common by indigenous communities to create a large class of yeoman farmers. Liberals passed a series of individual Reform laws and then wrote a new constitution in 1857 to give full force to the changes. Liberalism in Mexico "was not only a political philosophy of republicanism but a package including democratic social values, free enterprise, a legal bundle of civil rights to protect individualism, and a group consciousness of nationalism." Mexican liberalism is most closely associated with anticlericalism. Mexican liberals looked to the U.S. as their model for development and actively sought the support of the U.S., while Mexican conservatives looked to Europe.

In the history of Mexico, La Reforma, or reform laws, refers to a pivotal set of laws, including a new constitution, that were enacted in the Second Federal Republic of Mexico during the 1850s after the Plan of Ayutla overthrew the dictatorship of Santa Anna. They were intended as modernizing measures: social, political, and economic, aimed at undermining the traditional power of the Catholic Church and the army. The reforms sought separation of church and state, equality before the law, and economic development. These anticlerical laws were enacted in the Second Mexican Republic between 1855 and 1863, during the governments of Juan Álvarez, Ignacio Comonfort and Benito Juárez. The laws also limited the ability of Catholic Church and indigenous communities from collectively holding land. The liberal government sought the revenues from the disentailment of church property, which could fund the civil war against Mexican conservatives and to broaden the base of property ownership in Mexico and encouraging private enterprise. Several of them were raised to constitutional status by the constituent Congress that drafted the liberal Constitution of 1857. Although the laws had a major impact on the Catholic Church in Mexico, liberal proponents were not opposed to the church as a spiritual institution, but rather sought a secular state and a society not dominated by religion.