Lofton Russell Henderson was a United States Marine Corps aviator during World War II. He commanded Marine Scout Bombing Squadron 241 (VMSB-241) at the Battle of Midway and died while leading his squadron in an attack against Japanese aircraft carriers.

The Battle of Midway was a major naval battle in the Pacific Theater of World War II that took place 4–7 June 1942, six months after the Empire of Japan's attack on Pearl Harbor and one month after the Battle of the Coral Sea. The U.S. Navy under Admirals Chester W. Nimitz, Frank J. Fletcher, and Raymond A. Spruance defeated an attacking fleet of the Imperial Japanese Navy under Admirals Isoroku Yamamoto, Chūichi Nagumo, and Nobutake Kondō north of Midway Atoll, inflicting devastating damage on the Japanese fleet. Military historian John Keegan called it "the most stunning and decisive blow in the history of naval warfare", while naval historian Craig Symonds called it "one of the most consequential naval engagements in world history, ranking alongside Salamis, Trafalgar, and Tsushima Strait, as both tactically decisive and strategically influential."