Lonoke County is located in the Central Arkansas region of the U.S. state of Arkansas. As of the 2020 census, the population was 74,015, making it the 10th-most populous of Arkansas's 75 counties. The county seat is Lonoke and largest city is Cabot. Included in the Central Arkansas metropolitan area, with Little Rock as the principal city, it is an alcohol prohibition or dry county.

Central Arkansas, also known as the Little Rock metro, designated by the United States Office of Management and Budget as the Little Rock-North Little Rock-Conway Metropolitan Statistical Area, is the most populous metro area in the U.S. state of Arkansas. With an estimated 2020 population of 748,031, it is the most populated area in Arkansas. Located at the convergence of Arkansas's other geographic regions, the region's central location make Central Arkansas an important population, economic, education, and political center in Arkansas and the South. Little Rock is the state's capital and largest city, and the city is also home to two Fortune 500 companies, Arkansas Children's Hospital, and University of Arkansas for Medical Sciences (UAMS).