Loopy De Loop is a theatrical cartoon short series produced and directed by William Hanna and Joseph Barbera after leaving MGM and opening their new studio, Hanna-Barbera Productions. 48 cartoons were produced between 1959 and 1965, and released to theatres by Columbia Pictures. It was the final theatrical cartoon series to be produced by Bill Hanna and Joe Barbera, as well as the only one to be produced by their own studio.

William Denby Hanna was an American animator, voice actor, and occasional musician who is best known for co-creating Tom and Jerry and providing the vocal effects for the series' title characters. Alongside Joseph Barbera, he also founded the animation studio and production company Hanna-Barbera.