Lord Williams's School is a co-educational secondary school with academy status in Thame, Oxfordshire, England. The school takes children from the age of 11 through to the age of 18. The school has approximately 2,200 pupils.

Thame is a market town and civil parish in Oxfordshire, about 13 miles (21 km) east of the city of Oxford and 10 miles (16 km) southwest of Aylesbury. It derives its name from the River Thame which flows along the north side of the town and forms part of the county border with Buckinghamshire. The parish includes the hamlet of Moreton south of the town. The 2011 Census recorded the parish's population as 11,561. Thame was founded in the Anglo-Saxon era and was in the kingdom of Wessex.