Luigi Oreglia di Santo Stefano was a cardinal of the Catholic Church in the late nineteenth century. He was Bishop of Ostia e Velletri and Dean of the Sacred College of Cardinals from 1896 until his death.

The Roman Catholic Suburbicarian Diocese of Ostia is an ecclesiastical territory located within the Metropolitan City of Rome in Italy. It is one of the seven suburbicarian dioceses. The incumbent Bishop is cardinal Giovanni Battista Re. Since 1150, its bishop has been the Dean of the College of Cardinals. Its Cathedral is Basilica di Sant'Aurea.