The M6 motorway is the longest motorway in the United Kingdom. It is located entirely within England, running for just over 230 miles (370 km) from the Midlands to the border with Scotland. It begins at Junction 19 of the M1 and the western end of the A14 at the Catthorpe Interchange, near Rugby before heading north-west. It passes Coventry, Birmingham, Wolverhampton, Stoke-on-Trent, Preston, Lancaster and Carlisle before terminating at Junction 45 near Gretna. Here, just short of the Scottish border it becomes the A74(M) which continues to Glasgow as the M74. Its busiest sections are between junctions 4 and 10a in the West Midlands, and junctions 16 to 19 in Cheshire; these sections have now been converted to smart motorways.

The M1 motorway connects London to Leeds, where it joins the A1(M) near Aberford, to connect to Newcastle. It was the first inter-urban motorway to be completed in the UK; the first motorway in the country was the Preston Bypass, which later became part of the M6.