Madison County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 109,145. The county seat is Canton. The county is named for Founding Father and U.S. President James Madison.

The city of Canton is the county seat of Madison County, Mississippi, United States, and is situated in the northern part of the metropolitan area surrounding the state capital, Jackson. The population of Canton was 10,948 at the 2020 census, down from 13,189 in 2010.