Maine-et-Loire is a department in the Loire Valley in the Pays de la Loire region in Western France. It is named after the two rivers, Maine and the Loire. It borders Mayenne and Sarthe to the north, Loire-Atlantique to the west, Indre-et-Loire to the east, Vienne and Deux-Sèvres to the south, Vendée to the south-west, and Ille-et-Vilaine to the north-west. It also borders Ille-et-Vilaine in the north for just 20 yards (19 m), France's shortest department boundary. Its prefecture is Angers; its subprefectures are Cholet, Saumur and Segré-en-Anjou Bleu. Maine-et-Loire had a population of 818,273 in 2019.

The Loire Valley, spanning 280 kilometres (170 mi), is a valley located in the middle stretch of the Loire river in central France, in both the administrative regions Pays de la Loire and Centre-Val de Loire. The area of the Loire Valley comprises about 800 square kilometres (310 sq mi). It is referred to as the Cradle of the French and the Garden of France due to the abundance of vineyards, fruit orchards, and artichoke, and asparagus fields, which line the banks of the river. Notable for its historic towns, architecture, and wines, the valley has been inhabited since the Middle Palaeolithic period. The oldest known Neanderthal engravings have been found a cave in La Roche-Cotard which have been dated to more than 57,000 years ago. In 2000, UNESCO added the central part of the Loire River valley to its list of World Heritage Sites.