Margaret Lea Houston was First Lady of the Republic of Texas during her husband Sam Houston's second term as President of the Republic of Texas. They met following the first of his two non-consecutive terms as the Republic's president, and married when he was a representative in the Congress of the Republic of Texas. She was his third wife, remaining with him until his death.

Samuel Houston was an American general and statesman who played a prominent role in the Texas Revolution. He served as the first and third president of the Republic of Texas and was one of the first two individuals to represent Texas in the United States Senate. He also served as the sixth governor of Tennessee and the seventh governor of Texas, the only individual to be elected governor of two different states in the United States.