Margherita de' Medici was Duchess of Parma and Piacenza by her marriage to Odoardo Farnese, Duke of Parma. Margherita was regent of Piacenza in 1635, and regent of the entire duchy from 1646 until 1648 during the minority of her son.

Odoardo Farnese, also known as Odoardo I Farnese to distinguish him from his grandson Odoardo II Farnese, was Duke of Parma, Piacenza and Castro from 1622 to 1646.