Marlboro County is a county located in the Pee Dee region on the northern border of the U.S. state of South Carolina. As of the 2020 census, its population was 26,667. Its county seat is Bennettsville. The Great Pee Dee River runs through it.

The Pedee people, also Pee Dee and Peedee, were a historic Native American tribe of the Southeastern United States. Historically, their population has been concentrated in the Piedmont of present-day South Carolina. It is believed that in the 17th and 18th centuries, English colonists named the Pee Dee River and the Pee Dee region of South Carolina for the tribe. Today four state-recognized tribes, one state-recognized group, and several unrecognized groups claim descent from the historic Pedee people. Presently none of these organizations are recognized by the Bureau of Indian Affairs, with the Catawba Indian Nation being the only federally recognized tribe within South Carolina.