Megatherium is an extinct genus of ground sloths endemic to South America that lived from the Early Pliocene through the end of the Pleistocene. It is best known for the elephant-sized type species M. americanum, sometimes known as the giant ground sloth, or the megathere, native to the Pampas through southern Bolivia during the Pleistocene. Various other smaller species belonging to the subgenus Pseudomegatherium are known from the Andes.

Ground sloths are a diverse group of extinct sloths in the mammalian superorder Xenarthra. Ground sloths varied widely in size, with the largest, belonging to genera Megatherium and Eremotherium, being around the size of elephants. Ground sloths are a paraphyletic group, as living tree sloths are thought to have evolved from ground sloth ancestors.