Metlakatla is a census-designated place (CDP) on Annette Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2010 census the population was 1,405; this had grown to 1,454 by the 2020 census.

Prince of Wales–Hyder Census Area is a census area located in the U.S. state of Alaska. As of the 2020 census, the population was 5,753, up from 5,559 in 2010. It is part of the unorganized borough and therefore has no borough seat. Its largest communities are Metlakatla and Craig. It was formerly part of the Census Bureau's Prince of Wales–Outer Ketchikan Census Area, but the name was changed in 2008 after most of the Outer Ketchikan was lost to annexation by the Ketchikan Gateway Borough.