The Michigan State Spartans football program represents Michigan State University (MSU) in college football at the NCAA Division I Football Bowl Subdivision (FBS) level. The Spartans are members of the Big Ten Conference. Michigan State claims a total of six national championships, including two from major wire-service: AP Poll and/or Coaches' Poll. The Spartans have also won eleven conference championships, with two in the Michigan Intercollegiate Athletic Association and nine in the Big Ten.

Michigan State University is a public land-grant research university in East Lansing, Michigan. It was founded in 1855 as the Agricultural College of the State of Michigan, the first of its kind in the United States. After the introduction of the Morrill Act in 1862, the state designated the college a land-grant institution in 1863, making it the first of the land-grant colleges in the United States. The college became coeducational in 1870. Today, Michigan State has rapidly expanded its footprint across the state of Michigan with facilities all across the state and one of the largest collegiate alumni networks with 634,000 members.