Mighty Mouse is an American animated character created by the Terrytoons studio for 20th Century Fox. The character is a anthropomorphic superhero mouse, originally called Super Mouse, and made his debut in the 1942 short The Mouse of Tomorrow. The name was changed to Mighty Mouse in his eighth film, 1944's The Wreck of the Hesperus, and the character went on to star in 80 theatrical shorts, concluding in 1961 with Cat Alarm.

Terrytoons was an American animation studio in New Rochelle, New York, that produced animated cartoons for theatrical release from 1929 to 1973. Terrytoons was founded by Paul Terry, Frank Moser, and Joseph Coffman, and operated out of the "K" Building in downtown New Rochelle. The studio created many cartoon characters including Fanny Zilch, Mighty Mouse, Heckle and Jeckle, Gandy Goose, Sourpuss, Dinky Duck, Little Roquefort, the Terry Bears, Dimwit, and Luno; Terry's pre-existing character Farmer Al Falfa was also featured often in the series.