The Ministry of Health (MISAN) is the department of the Government of Spain responsible for proposing and executing the government policy on health, planning and providing healthcare as well as the exercise of the powers of the General State Administration to assure citizens the right to health protection. The Ministry is headquartered in the Paseo del Prado in Madrid, opposite the Prado Museum.

The Spanish government departments, commonly known as Ministries, are the main bodies through which the Government of Spain exercise its executive authority. They are also the top level of the General State Administration. The ministerial departments and their organization are created by Royal Decree signed by the Monarch and the Prime Minister and all of them are headed by a Cabinet member called Minister.