Minnesota State Highway 61 is a 150.321-mile-long (241.918 km) highway in northeast Minnesota, which runs from a junction with Interstate 35 (I-35) in Duluth at 26th Avenue East, and continues northeast to its northern terminus at the Canadian border near Grand Portage, connecting to Ontario Highway 61 at the Pigeon River Bridge. The route is a scenic highway, following the North Shore of Lake Superior, and is part of the Lake Superior Circle Tour designation that runs through Minnesota, Ontario, Michigan, and Wisconsin.

Interstate 35 (I-35) is a north–south Interstate Highway that stretches from Laredo, Texas, to Duluth, Minnesota. In the US state of Minnesota, I-35 enters from Iowa and heads north toward the twin cities of Minneapolis and Saint Paul. South of the metropolitan area, I-35 splits into two branches; I-35E runs through Saint Paul and I-35W through Minneapolis. These two branches rejoin north of the Twin Cities, and the highway continues north to Duluth, where it terminates at State Highway 61 (MN 61). The highway was authorized in 1956 and the first segment opened in 1958. It reached Duluth in 1971, and the final segment to east Duluth opened in 1992.