Mississippi is a state in the Southeastern region of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the southwest, and Arkansas to the northwest. Mississippi's western boundary is largely defined by the Mississippi River, or its historical course. Mississippi is the 32nd largest by area and 35th-most populous of the 50 U.S. states and has the lowest per-capita income. Jackson is both the state's capital and largest city. Greater Jackson is the state's most populous metropolitan area, with a population of 591,978 in 2020.

The Southeastern United States, also referred to as the American Southeast, the Southeast, or the South, is a geographical region of the United States located in the eastern portion of the Southern United States and the southern portion of the Eastern United States. The region includes a core of states that reaches north to Maryland and West Virginia, bordering the Ohio River and Mason–Dixon line, and stretches west to Arkansas and Louisiana.