Missouri is a landlocked state in the Midwestern region of the United States. Ranking 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the 18th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Springfield, and Columbia; the capital is Jefferson City.

The Midwestern United States, also referred to as the Midwest or the American Midwest, is one of four census regions of the United States Census Bureau. It occupies the northern central part of the United States. It was officially named the North Central Region by the U.S. Census Bureau until 1984. It is between the Northeastern United States and the Western United States, with Canada to the north and the Southern United States to the south.