Mohammed Burhanuddin was the 52nd Dā'ī al-Mutlaq of Dawoodi Bohras. He led the community for 49 years in a period of social, economic, and educational prosperity; strengthened and re-institutionalized the fundamental core of the community's faith; revived its culture, tradition, and heritage. In successfully achieving coexistence of traditional Islamic values and modern Western practices within the community, Burhanuddin completed the work his predecessor Taher Saifuddin had started. Burhanuddin was presented the highest national civilian honors of the states of Egypt and Jordan recognising his revivalism and restoration efforts. He was known in Arab countries as Azamat us-Sultan. Owing to extensive travels for community reach-out, he was the first Dā'ī al-Mutlaq to visit Europe, Australia, and America.

The term Da'i al-Mutlaq literally meaning 'the absolute, or unrestricted, missionary', is the most senior spiritual rank and office in Tayyibi Isma'ilism. The Da'i al-Mutlaq has headed the Tayyibi community since the seclusion of the 21st Tayyibi Imam, at-Tayyib Abu'l-Qasim, traditionally placed in 528 AH/1134 AD.