Mr. Irrelevant is the nickname given to the person drafted with the final pick of an NFL draft. Most players drafted with the very last draft pick do not even end up playing in an actual NFL game, let alone go on to having successful careers in the NFL. Oftentimes, a player chosen with this pick is released from the team that drafted them before preseason or training camps begin. Some notable exceptions include Jacque MacKinnon, Ryan Succop, and Brock Purdy.

The National Football League draft, also called the NFL draft or (officially) the Annual Player Selection Meeting, is an annual event which serves as the most common source of player recruitment in the National Football League. Each team is given a position in the drafting order in reverse order relative to its record in the previous year, which means that the last place team is positioned first and the Super Bowl champion is last. From this position, the team can either select a player or trade its position to another team for other draft positions, a player or players, or any combination thereof. The round is complete when each team has either selected a player or traded its position in the draft. The first draft was held in 1936, and has been held every year since.