The Muzaka were a noble Albanian family that ruled over the region of Myzeqe in the Late Middle Ages. The Muzaka are also referred to by some authors as a tribe or a clan. The earliest historical document that mentions the Muzaka family is written by the Byzantine historian Anna Komnene. At the end of the 13th and beginning of the 14th century members of the Muzaka family controlled a region between the rivers of Devoll and Vjosë. Some of them were loyal to the Byzantine Empire while some of them allied with Charles of Anjou who gave them impressive Byzantine-like titles in order to subdue them more easily. In the 1340s, Stefan Dušan pressed further south into Albania, and by 1343-45 had taken central towns and territories in southern Albania, including domains of the Muzaka family. However, they would fall back under local control after his death in 1555. After the Battle of Savra in 1385 the territory of Albania came under the Ottoman Empire; they served the Ottomans until 1444 when Theodor Corona Musachi joined Skanderbeg's rebellion. When the Ottomans suppressed Skanderbeg's rebellion and captured the territory of Venetian Albania in the 15th century many members of the Muzaka family retreated to Italy. Those who stayed in Ottoman Albania lost their feudal rights, some converted to Islam and achieved high ranks in the Ottoman military and administrative hierarchy.

The Myzeqe is a plain in the Western Lowlands of Albania. The Myzeqe is the largest and widest plain, measured by area, in the Lowlands.