Mwanza Region is one of Tanzania's 31 administrative regions. The region covers a land area of 25,233 km2 (9,743 sq mi). The region is comparable in size to the combined land area of the nation state of North Macedonia. Mwanza Region is bordered to the north through Lake Victoria by the Kagera Region and Mara Region, to the east by Simiyu Region, to the south by the Shinyanga Region and to the west by Geita Region. The regional capital is the city of Mwanza. According to the 2022 national census, the region had a population of 3,699,872 and national census of 2012 had 2,772,509. Mwanza Region is the second region with high population in Tanzania after Dar es Salaam Region.

Kagera Region is one of Tanzania's 31 administrative regions. The region covers an area of 35,686 km2 (13,778 sq mi). The region is comparable in size to the land area of the Netherlands. Kagera Region is bordered to the east by Lake Victoria, Mwanza Region and Mara Region. The region is bordered to the south by Geita Region and Kigoma Region. Lastly, Kagera borders Rwanda to the west, Uganda to the north and Burundi to the south west. The regional capital city is Bukoba. According to the 2022 national census, the region had a population of 2,989,299, an increase from 2,458,023 recorded in 2012.