The National Football League Kickoff Game, along with related festivities, marks the official start of the National Football League (NFL) regular season. A single game is held, preceded by a concert and other ceremonies. This first game of the season is usually scheduled for the Thursday following Labor Day. An exception was made in 2012, when the game was moved to Wednesday to prevent conflicts with the acceptance speech of the Democratic National Convention. Although the Kickoff Game is typically played on Thursday night, the league treats it separately from the Thursday Night Football games during the rest of the season.

The National Football League (NFL) is a professional American football league that consists of 32 teams, divided equally between the American Football Conference (AFC) and the National Football Conference (NFC). The NFL is one of the major professional sports leagues in the United States and Canada and the highest professional level of American football in the world. Each NFL season begins annually with a three-week preseason in August, followed by the 18-week regular season which runs from early September to early January, with each team playing 17 games and having one bye week. Following the conclusion of the regular season, seven teams from each conference advance to the playoffs, a single-elimination tournament that culminates in the Super Bowl, which is contested in February and is played between the winners of the AFC and NFC championship games.