Native American tribes in the U.S. state of Nebraska have been Plains Indians, descendants of succeeding cultures of indigenous peoples who have occupied the area for thousands of years. More than 15 historic tribes have been identified as having lived in, hunted in, or otherwise occupied territory within the current state boundaries.

Plains Indians or Indigenous peoples of the Great Plains and Canadian Prairies are the Native American tribes and First Nation band governments who have historically lived on the Interior Plains of North America. While hunting-farming cultures have lived on the Great Plains for centuries prior to European contact, the region is known for the horse cultures that flourished from the 17th century through the late 19th century. Their historic nomadism and armed resistance to domination by the government and military forces of Canada and the United States have made the Plains Indian culture groups an archetype in literature and art for Native Americans everywhere.