A nebula is a distinct luminescent part of interstellar medium, which can consist of ionized, neutral, or molecular hydrogen and also cosmic dust. Nebulae are often star-forming regions, such as in the "Pillars of Creation" in the Eagle Nebula. In these regions, the formations of gas, dust, and other materials "clump" together to form denser regions, which attract further matter and eventually become dense enough to form stars. The remaining material is then thought to form planets and other planetary system objects.

In astronomy, the interstellar medium (ISM) is the matter and radiation that exists in the space between the star systems in a galaxy. This matter includes gas in ionic, atomic, and molecular form, as well as dust and cosmic rays. It fills interstellar space and blends smoothly into the surrounding intergalactic space. The energy that occupies the same volume, in the form of electromagnetic radiation, is the interstellar radiation field. Although the density of atoms in the ISM is usually far below that in the best laboratory vacuums, the mean free path between collisions is short compared to typical interstellar lengths, so on these scales the ISM behaves as a gas (more precisely, as a plasma: it is everywhere at least slightly ionized), responding to pressure forces, and not as a collection of non-interacting particles.