New Hampshire Route 101 is a state-maintained highway in southern New Hampshire extending from Keene to Hampton Beach. It is the major east–west highway in the southern portion of the state. Most of its eastern portion is a major freeway linking the greater Manchester area to the Seacoast Region. At 95.189 miles (153.192 km) in length, NH 101 nearly spans the entire width of southern New Hampshire.

Keene is a city in Cheshire County, New Hampshire, United States. The population was 23,047 at the 2020 census, down from 23,409 at the 2010 census. It is the county seat and the only city in the county.