New Orleans East is the eastern section of New Orleans, Louisiana, the newest section of the city. This collection neighborhood sub divisions represents 65% of the city's total land area, but it is geographically isolated from the rest of the city by the Inner Harbor Navigational Canal. It is surrounded by water on all sides, bounded by the Industrial Canal, Gulf Intracoastal Waterway, Lake Pontchartrain, Lake Borgne, and the Rigolets, a long deep-water strait connecting the two lakes. Interstate 10 (I-10) splits the area nearly in half, and Chef Menteur Hwy, Downman Rd, Crowder Blvd, Dwyer Rd, Lake Forest Blvd, Read Blvd, Bullard Ave, Michoud Blvd, Hayne Blvd, Morrison Rd, Bundy Rd, and Almonaster Ave serve as major streets and corridors.

U.S. Highway 90 (US 90), one of the major east–west U.S. Highways in the Southern United States, runs through southern Louisiana for 297.6 miles (478.9 km), serving Lake Charles, Lafayette, New Iberia, Morgan City, and New Orleans. Much of it west of Lafayette and east of New Orleans has been supplanted by Interstate 10 (I-10) for all but local traffic, but the section between Lafayette and New Orleans runs a good deal south of I-10.