Ningishzida was a Mesopotamian deity of vegetation, the underworld and sometimes war. He was commonly associated with snakes. Like Dumuzi, he was believed to spend a part of the year in the land of the dead. He also shared many of his functions with his father Ninazu.

The ancient Mesopotamian underworld, most often known in Sumerian as Kur, Irkalla, Kukku, Arali, or Kigal and in Akkadian as Erṣetu, although it had many names in both languages, was a dark, dreary cavern located deep below the ground, where inhabitants were believed to continue "a transpositional version of life on earth". The only food or drink was dry dust, but family members of the deceased would pour sacred mineral libations from the earth for them to drink. In the Sumerian underworld, it was initially believed that there was no final judgement of the deceased and the dead were neither punished nor rewarded for their deeds in life.