The 2001 No Way Out was the third No Way Out professional wrestling pay-per-view (PPV) event produced by the World Wrestling Federation. It took place on February 25, 2001, at the Thomas & Mack Center in the Las Vegas suburb of Paradise, Nevada. This was the last WWF PPV of the Monday Night Wars era of September 4, 1995, to March 26, 2001, during which the WWF's Monday Night Raw and World Championship Wrestling (WCW)'s Monday Nitro competed for ratings in a weekly Monday night time slot, which is now widely seen as the "golden age" of professional wrestling. The show is widely considered to be one of the greatest WWE pay-per-views of all time.

The Thomas & Mack Center is a multi-purpose arena located on the campus of the University of Nevada, Las Vegas in Paradise, Nevada. It is home of the UNLV Runnin' Rebels basketball team of the Mountain West Conference.