North Carolina's 6th congressional district is located in north central portion of the state. As a result of court-mandated redistricting in 2019, it was shifted into the central Triad region and contains all of Guilford County and a portion of Forsyth County. The cities of Greensboro, Winston-Salem, and High Point are located in the district.

Guilford County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 541,299, making it the third-most populous county in North Carolina. The county seat and largest community is Greensboro. Since 1938, an additional county court has been located in High Point. The county was formed in 1771. Guilford County is included in the Greensboro-High Point, NC Metropolitan Statistical Area, which is also included in the Greensboro–Winston-Salem–High Point, NC Combined Statistical Area.