North Carolina Highway 54 (NC 54) is a 55.0-mile-long (88.5 km) primary state highway in the U.S. state of North Carolina. The highway serves the Research Triangle area, between Burlington and Raleigh, connecting the cities and towns of Chapel Hill, Durham, Morrisville and Cary. The highway also links the campuses of University of North Carolina at Chapel Hill and North Carolina State University.

Morrisville is a town located primarily in Wake County, North Carolina, United States. According to the 2020 census, the population was 29,630. Morrisville is part of the Research Triangle metropolitan region. The regional name originated after the 1959 creation of the Research Triangle Park, located midway between the cities of Raleigh and Durham. The Research Triangle region encompasses the Raleigh-Durham-Cary, NC Combined Statistical Area. The population of the Raleigh-Durham-Cary, NC Combined Statistical Area was 2,106,463 in 2020, while the population of the Raleigh-Cary, NC Metropolitan Statistical Area was 1,413,982 in 2020. The operational headquarters of Lenovo is located in the municipal limits.