The North Luzon Expressway (NLEX), signed as E1 of the Philippine expressway network, partially as N160 of the Philippine highway network, and partially as R-8 of the Metro Manila arterial road network, is a controlled-access highway that connects Metro Manila to the provinces of the Central Luzon region in the Philippines. The expressway, which includes the main segment and its various spurs, has a total length of 101.8 kilometers (63.3 mi) and travels from its northern terminus at Santa Ines Interchange to its southern terminus in Balintawak Interchange, which is adjacent to its connection to Skyway, an elevated toll road that connects the NLEX to its counterpart in the south, the South Luzon Expressway. The segment of the expressway between Santa Rita Exit in Guiguinto and the Balintawak Interchange in Quezon City is part of Asian Highway 26 of the Asian highway network. Despite that the name stating the word "North Luzon", the expressway only ends at Santa Ines Exit at Mabalacat, Pampanga which is located in Central Luzon.

The Philippine expressway network, also known as the High Standard Highway Network, is a controlled-access highway network managed by the Department of Public Works and Highways (DPWH) which consists of all expressways and regional high standard highways in the Philippines.