Northampton railway station serves the county town of Northampton in England. It is on the Northampton Loop of the West Coast Main Line and is located 65 miles 68 chains from London Euston. The station is served by West Midlands Trains services between London Euston and Birmingham New Street; there is also a limited direct service to Crewe. A handful of Avanti West Coast services also serve the station, but these have been greatly reduced due to the longer-term impact of the COVID-19 pandemic in the United Kingdom. It is the busiest station in Northamptonshire, and the fourth busiest station in the East Midlands.

Northampton is a town and civil parish in Northamptonshire, England. It is the county town of Northamptonshire and the administrative centre of the unitary authority of West Northamptonshire. The town is situated on the River Nene, 60 miles (97 km) north-west of London and 50 miles (80 km) south-east of Birmingham. Northampton is one of the largest towns in England; the population of its overall urban area was recorded as 249,093 in the 2021 census.