The region Northeast Ohio, in the US state of Ohio, in its most expansive usage contains six metropolitan statistical areas: Cleveland–Elyria, Akron, Canton–Massillon, Youngstown–Warren, Mansfield, and Weirton–Steubenville along with eight micropolitan statistical areas. Most of the region is considered either part of the Cleveland–Akron–Canton, OH Combined Statistical Area and media market or the Youngstown–Warren, OH–PA Combined Statistical Area and media market. In all, the region is home to: 4,502,460 residents. It is also a part of the Great Lakes megalopolis, containing over 54 million people. Northeast Ohio also includes most of the area known historically as the Connecticut Western Reserve.

Ohio is a state in the Midwestern region of the United States. Ohio borders Lake Erie to the north, Pennsylvania to the east, West Virginia to the southeast, Kentucky to the southwest, Indiana to the west, and Michigan to the northwest. Of the 50 U.S. states, it is the 34th-largest by area. With a population of nearly 11.8 million, Ohio is the seventh-most populous and tenth-most densely populated state. Its capital and most populous city is Columbus, with other large population centers including Cleveland, Cincinnati, Dayton, Akron, and Toledo. Ohio is nicknamed the "Buckeye State" after its Ohio buckeye trees, and Ohioans are also known as "Buckeyes". Its flag is the only non-rectangular flag of all U.S. states.