The Central Valleys of Oaxaca, also simply known as the Oaxaca Valley, is a geographic region located within the modern-day state of Oaxaca in southern Mexico. In an administrative context, it has been defined as comprising the districts of Etla, Centro, Zaachila, Zimatlán, Ocotlán, Tlacolula and Ejutla. The valley, which is located within the Sierra Madre Mountains, is shaped like a distorted and almost upside-down “Y,” with each of its arms bearing specific names: the northwestern Etla arm, the central southern Valle Grande, and the Tlacolula arm to the east. The Oaxaca Valley was home to the Zapotec civilization, one of the earliest complex societies in Mesoamerica, and the later Mixtec culture. A number of important and well-known archaeological sites are found in the Oaxaca Valley, including Monte Albán, Mitla, San José Mogote and Yagul. Today, the capital of the state, the city of Oaxaca, is located in the central portion of the valley.

Oaxaca, officially the Free and Sovereign State of Oaxaca, is one of the 32 states that compose the Federative Entities of the United Mexican States. It is divided into 570 municipalities, of which 418 are governed by the system of usos y costumbres with recognized local forms of self-governance. Its capital city is Oaxaca de Juárez.