State Route 32 (SR 32), also known as the James A. Rhodes Appalachian Highway, is a major east–west highway across the southern portion of the U.S. state of Ohio. It is the eighth longest state route in Ohio, spanning southern Ohio from Cincinnati to Belpre, across the Ohio River from Parkersburg, West Virginia. Except in Belpre, leading up to the bridge into West Virginia, the entire route outside Cincinnati's beltway is a high-speed four-lane divided highway, forming the Ohio portion of Corridor D of the Appalachian Development Highway System.

Interstate 275 (I-275) is an 83.71-mile-long (134.72 km) highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania. It is the longest beltway with an Interstate highway designation in the United States, enclosing an area of over 250,000 acres (100,000 ha). It is also the third longest beltway overall in the United States; only the Sam Houston Tollway and the Grand Parkway, both encircling Greater Houston, are longer. For a short distance in northwest Hamilton County, it overlaps with I-74 and US Route 52 (US 52).