State Highway 152 is a state highway running through west-central Oklahoma. It begins at the Texas state line, serving as a continuation of Texas State Highway 152, and continues east to end at Interstate 44 (I-44) in southwest Oklahoma City, a length of 149.2 miles (240.1 km). Along its route it serves three county seats: Sayre, Cordell, and Oklahoma City. Near its eastern end, it passes through the Oklahoma City suburb of Mustang. The easternmost 5.2 miles (8.4 km) of the route is a freeway linking Will Rogers World Airport to the Interstate system, this section will be truncated in 2024 and will be a part of I-240. SH-152 has no lettered spur routes.

Interstate 44 (I-44) is an Interstate Highway that runs diagonally through the U.S. state of Oklahoma, spanning from the Texas state line near Wichita Falls, Texas, to the Missouri border near Joplin, Missouri. It connects three of Oklahoma's largest cities: Oklahoma City, Tulsa, and Lawton. Most of I-44 in Oklahoma is a toll road. In southwestern Oklahoma, I-44 is the H. E. Bailey Turnpike and follows a diagonally northwest–southeast direction. From Oklahoma City to Tulsa, I-44 follows the Turner Turnpike. As I-44 leaves Tulsa, it becomes the Will Rogers Turnpike to the Missouri border. In the Lawton, Oklahoma City, and Tulsa metropolitan areas, I-44 is toll-free. In Oklahoma City, I-44 is also known as the Will Rogers Expressway.