Opie and Anthony was an American radio show hosted by Gregg "Opie" Hughes and Anthony Cumia that aired from March 1995 to July 2014, with comedian Jim Norton serving as third mic from 2001. The show originated in 1994 when Cumia took part in a song parody contest on Hughes' nighttime show on WBAB on Long Island, New York. After subsequent appearances, Cumia decided to pursue a radio career and teamed with Hughes to host their own show.

Gregg Hughes better known by his air name Opie, is an American radio personality and podcast host best known as the former co-host of the Opie and Anthony radio show that aired from 1995 to 2014 with Anthony Cumia and comedian Jim Norton. From 2014 to 2016, Hughes and Norton stayed at SiriusXM as co-hosts of Opie with Jim Norton. In October 2016, Hughes became the host of his own show, The Opie Radio Show, which lasted until his firing, for filming an employee as he used the toilet, on July 7, 2017.