Paisley Grammar School is a secondary school in Paisley, the largest town in Renfrewshire, Scotland. The school was founded in 1576 by royal charter of King James VI and is situated on Glasgow Road. The school is recognised as one of Scotland's oldest schools with an established history.

Paisley is a large town situated in the west central Lowlands of Scotland. Located north of the Gleniffer Braes, the town borders the city of Glasgow to the east, and straddles the banks of the White Cart Water, a tributary of the River Clyde.