Pan American-Grace Airways, also known as Panagra, and dubbed "The World's Friendliest Airline" was an airline formed as a joint venture between Pan American World Airways and Grace Shipping Company. On September 13, 1928, a small single-engine Fairchild airliner flew from Lima, Peru, to Talara, Peru, which marked not only the beginning of Pan American Grace Airways but also the inauguration of scheduled air transportation along the West Coast of South America. From this short flight in 1928 to nonstop flights from New York to South America with Douglas DC-8 Intercontinental Jets in 1966, Panagra became the standard-bearer for transportation between the US Mainland East Coast and the West Coast of South America for 39 years. The "World's Friendliest Airline" merged with Braniff International Airways in 1967, and the combined carrier became the largest US airline serving South America.

Pan American World Airways, originally founded as Pan American Airways and more commonly known as Pan Am, was an airline that was the principal and largest international air carrier and unofficial overseas flag carrier of the United States for much of the 20th century. It was the first airline to fly worldwide and pioneered numerous innovations of the modern airline industry, such as jumbo jets and computerized reservation systems. Until its dissolution on December 4, 1991, Pan Am "epitomized the luxury and glamour of intercontinental travel", and it remains a cultural icon of the 20th century, identified by its blue globe logo, the use of the word "Clipper" in its aircraft names and call signs, and the white uniform caps of its pilots.