Pemiscot County is a county located in the southeastern corner in the Bootheel in the U.S. state of Missouri, with the Mississippi River forming its eastern border. As of the 2020 census, the population was 15,661. The largest city and county seat is Caruthersville. The county was officially organized on February 19, 1851. It is named for the local bayou, taken from the word pem-eskaw, meaning "liquid mud", in the language of the native Fox (Meskwaki) people. This has been an area of cotton plantations and later other commodity crops.

The Missouri Bootheel is a salient (protrusion) located in the southeasternmost part of the U.S. state of Missouri, extending south of 36°30′ north latitude, so called because its shape in relation to the rest of the state resembles the heel of a boot. Strictly speaking, it is composed of some or all of the counties of Dunklin, New Madrid, and Pemiscot. However, the term is locally used to refer to the entire southeastern lowlands of Missouri located within the Mississippi Embayment, which includes parts of Butler, Mississippi, Ripley, Scott, Stoddard and extreme southern portions of Cape Girardeau and Bollinger counties. The largest city in the region is Kennett.